Chondroitin sulphate given orally was found to be effective in reducing pain, improving function, and reducing NSAID and analgesic consumption in seven randomised double-blind trials involving 702 patients with osteoarthritis of hip or knee over three months or more.
Searching of several electronic databases was for randomised, double-blind studies of chondroitin sulphate in osteoarthritis of hip or knee. Outcomes of interest were: Lequesne index, patient or physician global evaluation, pain, or walking time, or NSAID or analgesic drug use. Baseline characteristics had to show that patient characteristics were homogeneous.